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Every cell within him has changed, in his body and his mind.
Origin and General Application
Perhaps you know the tale of Terrigenesis."
"Of course. Ancient Kree descending on planets, altering its inhabitants to fight in their war.
Terrigenesis is a process developed by a radical faction of the Kree race during their experiments to create living weapons to serve as new soldiers in a prolonged war. By performing numerous genetic modifications to various intergalactic races, the Kree planned to expose individuals to the mist produced by Terrigen Crystals, sparking the Terrigenesis process, which would manifest diverse biological changes and powerful abilities that could be weaponized. On Earth, the Kree were forced to abandon their experiments, but left behind their test subjects, who would become the Inhumans, and several Terrigen Crystals that they had hidden away. 
Centuries later, a small fringe society of Inhumans had gathered together in China's Hunan Province. Within this society, certain members were allowed to undergo Terrigenesis to obtain their hidden gifts when they reached a certain adolescent age, an age when their elders believed they had developed enough to endure the changes, but were still young enough to adapt to it. One Inhuman, Jiaying, who had received extended longevity through Terrigenesis, was charged with guiding the generations of newly emerging Inhumans through their changes and help them harness their new abilities. One of these new Inhumans was Gordon, who emerged from Terrigenesis with the power of teleportation, but lost his eyes, with a layer of flesh covering the area where his eye sockets once were. Gordon eventually grew to master his powers and took upon himself Jiaying's responsibility of guiding new Inhumans as she had once guided him.
Within the settlement, named Afterlife in English, newly transformed Inhumans would be given a form of acupuncture involving small, shining needles that helped the body to adapt to the thousands of years of evolution which took place within moments. The "transitioner", the person who gave the acupuncture, would later train the person in how to use his power.
The entrances to the chamber started to close and the Diviner opened, revealing Terrigen Crystals. The crystals grew and released the Terrigen Mist, which caused Skye and Raina to form black, goo-like cocoons and to petrify. After a few seconds the cocoons crumbled, revealing Skye and Raina had unleashed their Inhuman potential.
Jemma Simmons did a chemical analysis of Raina's blood; she found that Raina's DNA was altered on a molecular level with the addition of macro-molecules.
During the War against the Inhumans, Skye used her powers to push a Quinjet filled with artificially-created Terrigen Crystals into the sea; these crystals dissolved in the water, releasing Terrigen Mist which contaminated the wildlife and were eventually turned into Nature Max Supplements Fish Oil pills which were distributed worldwide. Taking these pills caused other Inhumans to undergo Terrigenesis. One example was Joey Gutierrez; inside his apartment in Seattle, Washington, Gutierrez emerged from a cocoon with the ability to melt metal in his proximity.
- In the comics, the Inhumans going through the process of Terrigenesis form an actual, insect-like cocoon, and they can undergo Terrigenesis multiple times.